Breaking the Mold: How 3D-Printed Columns Eliminate Clogging in Bioprocessing

Column clogging and back-pressure spikes have long been the bane of biomanufacturing and downstream processing.

In an August 2024 feature for Analytical Chemistry Startups, science writer Adam Washburn sat down with our CEO, Dr. Sean Feast, for a technical deep dive into how Precision Chroma’s Printed Monolith Adsorption (PMA) technology is breaking the mold in protein purification.

The article explores how our design-engineered, uniform 3D channel structures overcome the historical scale-up failures of legacy systems like 1990s expanded bed adsorption (EBA). By utilizing customisable hydrogel and cellulose materials, our PMA columns allow messy, solid-laden biological products—such as cell-laden IgG cultures or solutions with up to 50% wet-weight yeast cells—to be purified in a single step without show-stopping clogs or pre-column filtration steps.

The interview also covers the academic origins of our technology in Dr. Conan Fee’s lab at the University of Canterbury, the potential long-term crossover into analytical separations, and our roadmap for international partner commercialization.

Read the full technical feature and interview over at: https://www.analyticalchemistrystartups.com/post/breaking-the-mold-with-3d-printed-chromatography